Article
Complement 4 gene deletion in patients with IgA nephropathy and Henoch-Schönlein nephritis.
Child nephrology and urology - 1 Jan 1992
Jin D K, Kohsaka T, Jun A, Kobayashi N
Abstract excerpt
The fourth component of complement (C4), especially B isotype, has been said to be deficient in the IgA nephropathy and Henoch-Schönlein nephritis. However, the association between these diseases and C4 deficiency was questioned recently, and the usual C4 allotyping method is unable to discriminate the C4 deficiency from the C4 duplication. So by combining the DNA restriction fragment length polymorphism with the...
Topics
- Child
- Complement C4
- Gene Deletion
- Glomerulonephritis, IGA
- Humans
- IgA Vasculitis
- Nephritis
- Phenotype
- Polymorphism, Restriction Fragment Length