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Article

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

Journal of autoimmunity - 1 Aug 2005

Ittiprasert Wannaporn, Kantachuvesiri Surasak, Pavasuthipaisit Kanok, Verasertniyom Orawan, Chaomthum Lulin, Totemchokchyakarn Kitti, Kitiyanant Yindee

Abstract excerpt

The complement component C4 is encoded by two genes: C4A and C4B on human chromosome 6p in the major histocompatibility complex (MHC). Most studies have linked the deficiencies in C4 with systemic lupus erythematosus (SLE) in Angio-Irish, North American, Black American, Mexican American, Australian and Japanese populations. Null alleles at either locus (C4AQ0 or C4BQ0) are relatively common in Americans occurring...

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PMID: 15998580
DOI: 10.1016/j.jaut.2005.04.004

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ACR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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