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Article

C4A and C4B null alleles are genetic markers of different types of systemic sclerosis in Japanese patients.

Clinical and experimental rheumatology - 1 Jan 2000

Takeuchi F, Nabeta H, Hong G H, Matsuta K, Tokunaga K, Tanimoto K, Nakano K

Abstract excerpt

OBJECTIVE: The contribution of the polymorphism of complement C4A and C4B alleles to the pathogenesis of systemic sclerosis (SSc) was studied in Japanese patients. METHODS: C4A and C4B typing was carried out in 44 SSc patients and in 83 normal subjects using electrophoresis followed by immunofixation and immunoblotting. HLA-DR typing and HLA DRB1*15 and *08 genotyping were carried out by the PCR method and the...

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PMID: 9543562

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