Article
Gag-CA Q110D mutation elicits TRIM5-independent enhancement of HIV-1mt replication in macaque cells.
Microbes and infection - 1 Jan 2013
Nomaguchi Masako, Yokoyama Masaru, Kono Ken, Nakayama Emi E, Shioda Tatsuo, Saito Akatsuki, Akari Hirofumi, Yasutomi Yasuhiro, Matano Tetsuro, Sato Hironori, Adachi Akio
Abstract excerpt
HIV-1 is strictly adapted to humans, and cause disease-inducing persistent infection only in humans. We have generated a series of macaque-tropic HIV-1 (HIV-1mt) to establish non-human primate models for basic and clinical studies. HIV-1mt clones available to date grow poorly in macaque cells relative to SIVmac239. In this study, viral adaptive mutation in macaque cells, G114E in capsid (CA) helix 6 of HIV-1mt,...
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