Article
Dynamic allostery governs cyclophilin A-HIV capsid interplay.
Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2015
Lu Manman, Hou Guangjin, Zhang Huilan, Suiter Christopher L, Ahn Jinwoo, Byeon In-Ja L, Perilla Juan R, Langmead Christopher J, Hung Ivan, Gor'kov Peter L, Gan Zhehong, Brey William, Aiken Christopher, Zhang Peijun, Schulten Klaus, Gronenborn Angela M, Polenova Tatyana
Abstract excerpt
Host factor protein Cyclophilin A (CypA) regulates HIV-1 viral infectivity through direct interactions with the viral capsid, by an unknown mechanism. CypA can either promote or inhibit viral infection, depending on host cell type and HIV-1 capsid (CA) protein sequence. We have examined the role of conformational dynamics on the nanosecond to millisecond timescale in HIV-1 CA assemblies in the escape from CypA...
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