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An antibody blocking IL-1 receptor accessory protein reduces cardiac inflammation and preserves heart function in viral and autoimmune myocarditis

2023-06-09

Abstract excerpt

<title>Abstract</title> <p>IL-1, IL-33 and IL-36 have complementary pro-inflammatory roles during the immune response promoting autoimmune and inflammatory diseases, such as myocarditis. Therapeutic blockers targeting the IL-1 pathway have previously been developed. However, we hypothesized that blockade of the shared co-receptor of these three pathways, IL-1 receptor accessory protein (IL1RAP), would exhibit a m...

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Literature Corpus work
377bbd5d-151e-51ae-a831-d29793ca15f3
DOI
10.21203/rs.3.rs-3007053/v1
Open publication

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An antibody blocking IL-1 receptor accessory protein reduces cardiac inflammation and preserves heart function in viral and autoimmune myocarditisDOI 10.21203/rs.3.rs-3007053/v1
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