Article

Rapid differentiation of regulatory CD4 <sup>+</sup> T cells in the infarcted myocardium blunts in situ inflammation

2022-03-27

Abstract excerpt

<h4>Background</h4> Myocardial infarction (MI) is a sterile inflammatory condition associated with tissue injury that results in the activation of T helper cell targeting cardiac antigens. However, the differentiation trajectories and in situ activity of heart-specific CD4 + T cells activated in the MI context remain poorly understood. <h4>Methods</h4> Herein, we combined T-cell receptor transgenic models tar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd837b5e-732b-5099-88c5-3e51c39b1840
DOI: 10.1101/2022.03.25.485791

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rapid differentiation of regulatory CD4 <sup>+</sup> T cells in the infarcted myocardium blunts in situ inflammationDOI 10.1101/2022.03.25.485791Read

Myocardial Milieu Favors Local Differentiation of Regulatory T CellsSemantic proximity Read

Persistent transcriptional changes in cardiac adaptive immune cells following myocardial infarction: New evidence from the re-analysis of publicly available single cell and nuclei RNA-sequencing data setsSemantic proximity Read

A distinct T cell receptor signature associates with cardiac outcome in myocardial infarction patientsSemantic proximity Read

Tregs delivered post-myocardial infarction adopt an injury-specific phenotype promoting cardiac repair via macrophages in mice.Semantic proximity Read

Endothelial cells adopt a pro-reparative immune responsive signature during cardiac injurySemantic proximity Read

Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesisSemantic proximity Read

Combined Checkpoint Inhibition Amplifies Post-Infarction Injury via T Cell-Mediated Macrophage ActivationSemantic proximity Read

Single‐Cell RNA Sequencing Reveals the Temporal Diversity and Dynamics of Cardiac Immunity after Myocardial InfarctionSemantic proximity Read

Phenotypes and mechanisms of dysfunctional cardiac T-lymphocytes in dilated cardiomyopathy patients.Semantic proximity Read

Lymphocytes at the Heart of Wound Healing.Semantic proximity Read

CD40 is an immune checkpoint regulator that potentiates myocardial inflammation through activation and expansion of CCR2 <sup>+</sup> macrophages and CD8 T-cellsSemantic proximity Read

Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure.Semantic proximity Read