Article
Prominin-1+/CD133+ bone marrow-derived heart-resident cells suppress experimental autoimmune myocarditis.
Cardiovascular research - 1 Nov 2008
Kania Gabriela, Blyszczuk Przemyslaw, Valaperti Alan, Dieterle Thomas, Leimenstoll Bernd, Dirnhofer Stephan, Zulewski Henryk, Eriksson Urs
Abstract excerpt
AIMS: Experimental autoimmune myocarditis (EAM) is a CD4(+) T cell-mediated mouse model of inflammatory heart disease. Tissue-resident bone marrow-derived cells adopt different cellular phenotypes depending on the local milieu. We expanded a specific population of bone marrow-derived prominin-1-expressing progenitor cells (PPC) from healthy heart tissue, analysed their plasticity, and evaluated their capacity to...
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