Article
Different angiogenic potential in low and high grade sporadic clear cell renal cell carcinoma is not related to alterations in the von Hippel-Lindau gene.
Cellular oncology : the official journal of the International Society for Cellular Oncology - 1 Jan 2009
Baldewijns Marcella M, van Vlodrop Iris J H, Smits Kim M, Vermeulen Peter B, Van den Eynden Gert G, Schot Fiona, Roskams Tania, van Poppel Hein, van Engeland Manon, de Bruïne Adriaan P
Abstract excerpt
BACKGROUND: von Hippel-Lindau (VHL) inactivation is common in sporadic clear cell renal cell carcinomas (ccRCC). pVHL is part of the ubiquitin ligase complex that targets the alpha subunits of hypoxia-inducible transcription factor (HIF) for degradation under well-oxygenated conditions. In the absence of wild-type pVHL, as observed in VHL patients and most sporadic ccRCCs, constitutive upregulation of HIF results...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.