Article
Absence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma.
British journal of cancer - 20 Oct 2009
Patard J-J, Rioux-Leclercq N, Masson D, Zerrouki S, Jouan F, Collet N, Dubourg C, Lobel B, Denis M, Fergelot P
Abstract excerpt
BACKGROUND: The von Hippel-Lindau gene (VHL) alteration, a common event in sporadic clear-cell renal-cell carcinoma (CCRCC), leads to highly vascularised tumours. Vascular endothelial growth factor (VEGF) is the major factor involved in angiogenesis, but the prognostic significance of both VHL inactivation and VEGF expression remain controversial. The aims of this study were to analyse the relationship between...
Topics
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Renal Cell
- DNA Methylation
- Female
- Humans
- Kidney Neoplasms
- Male
- Middle Aged
- Mutation
- Vascular Endothelial Growth Factor A
- Von Hippel-Lindau Tumor Suppressor Protein