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Article

VHL genetic alteration in CCRCC does not determine de-regulation of HIF, CAIX, hnRNP A2/B1 and osteopontin.

Cellular oncology (Dordrecht, Netherlands) - 1 Jun 2011

Nyhan Michelle J, El Mashad Shereen M, O'Donovan Tracey R, Ahmad Sarfraz, Collins Chris, Sweeney Paul, Rogers Eamonn, O'Sullivan Gerald C, McKenna Sharon L

Abstract excerpt

BACKGROUND: Von Hippel-Lindau (VHL) tumour suppressor gene inactivation is associated with clear cell renal cell carcinoma (CCRCC) development. The VHL protein (pVHL) has been proposed to regulate the expression of several proteins including Hypoxia Inducible Factor-α (HIF-α), carbonic anhydrase (CA)IX, heterogeneous nuclear ribonucleoprotein (hnRNP)A2/B1 and osteopontin. pVHL has been characterized in vitro,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21547579
DOI: 10.1007/s13402-011-0029-5
PMCID: PMC13014577

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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VHL genetic alteration in CCRCC does not determine de-regulation of HIF, CAIX, hnRNP A2/B1 and osteopontin.PMID 21547579Read ↗

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