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Article

VHL and HIF-1α: gene variations and prognosis in early-stage clear cell renal cell carcinoma.

Medical oncology (Northwood, London, England) - 1 Mar 2014

Lessi Francesca, Mazzanti Chiara Maria, Tomei Sara, Di Cristofano Claudio, Minervini Andrea, Menicagli Michele, Apollo Alessandro, Masieri Lorenzo, Collecchi Paola, Minervini Riccardo, Carini Marco, Bevilacqua Generoso

Abstract excerpt

Von Hipple-Lindau gene (VHL) inactivation represents the most frequent abnormality in clear cell renal cell carcinoma (ccRCC). Hypoxia-inducible factor-1α (HIF-1α) expression is regulated by O2 level. In normal O2 conditions, VHL binds HIF-1α and allows HIF-1α proteasomal degradation. A single-nucleotide polymorphism (SNP) has been found located in the oxygen-dependent degradation domain at codon 582 (C1772T,...

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Share to Carcinoma, Renal Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24446253
DOI: 10.1007/s12032-014-0840-8

Genes

VHL

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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