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Article

Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinoma

1 May 2005

Abstract excerpt

Somatic inactivation of the von Hippel-Lindau (VHL) gene is the most frequent genetic event observed in clear cell renal cell carcinoma (CC-RCC). However, the prognostic relevance of somatic VHL alteration and its target, hypoxia inducible factor (HIF)-1alpha has not been defined. We investigated the genetic changes in the VHL gene and HIF-1alpha and studied their clinical implications in patients with sporadic...

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Share to Cancer, Hypoxia, and Metabolism
Share to Epigenetics and DNA Methylation
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PMID: 15809750
DOI: 10.3892/or.13.5.859

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