Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma.

The Journal of pathology - 1 Feb 2002

Schraml Peter, Struckmann Kirsten, Hatz Florian, Sonnet Stefan, Kully Charlotte, Gasser Thomas, Sauter Guido, Mihatsch Michael J, Moch Holger

Abstract excerpt

Mutations of the von Hippel-Lindau (VHL) gene are considered critical for the initiation of clear cell renal cell carcinoma. The VHL protein is involved in regulation of the cell cycle and neo-vascularization. In this study, the association of VHL mutations with tumour cell proliferation, angiogenesis, and clinical outcome was analysed in 113 clear cell renal cell carcinomas. The degree of angiogenesis and tumour...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Renal Cell
Share to Ki-67 Antigen

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Kidney Neoplasms

Share to Ligases

Share to Neovascularization, Pathologic

Share to Survival Rate

Share to Ubiquitin-Protein Ligases

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 11793370
DOI: 10.1002/path.1034

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma.PMID 11793370Read ↗

Mutational status of VHL gene and its clinical importance in renal clear cell carcinoma.Semantic proximity Read ↗

Implication of VHL, ERK5, and HIF-1alpha in clear cell renal cell carcinoma: Molecular basis.Semantic proximity Read ↗

Clinicopathologic Significance of VHL Gene Alteration in Clear-Cell Renal Cell Carcinoma: An Updated Meta-Analysis and Review.Semantic proximity Read ↗

von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma.Semantic proximity Read ↗

The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma.Semantic proximity Read ↗

Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinomaSemantic proximity Read ↗

Different angiogenic potential in low and high grade sporadic clear cell renal cell carcinoma is not related to alterations in the von Hippel-Lindau gene.Semantic proximity Read ↗

Genetic pathways involved in carcinogenesis of clear cell renal cell carcinoma: genomics towards personalized medicine.Semantic proximity Read ↗

Absence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma.Semantic proximity Read ↗

The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma.Semantic proximity Read ↗

Polymorphisms in the Von Hippel-Lindau Gene Are Associated With Overall Survival in Metastatic Clear-Cell Renal-Cell Carcinoma Patients Treated With VEGFR Tyrosine Kinase Inhibitors.Semantic proximity Read ↗

VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.