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Article

VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma.

The Journal of pathology - 1 Feb 2002

Schraml Peter, Struckmann Kirsten, Hatz Florian, Sonnet Stefan, Kully Charlotte, Gasser Thomas, Sauter Guido, Mihatsch Michael J, Moch Holger

Abstract excerpt

Mutations of the von Hippel-Lindau (VHL) gene are considered critical for the initiation of clear cell renal cell carcinoma. The VHL protein is involved in regulation of the cell cycle and neo-vascularization. In this study, the association of VHL mutations with tumour cell proliferation, angioge...

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Share to Carcinoma, Renal Cell
Share to Ki-67 Antigen
Share to Kidney Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neovascularization, Pathologic

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Share to Ubiquitin-Protein Ligases

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 11793370
DOI: 10.1002/path.1034

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11793370-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma.PMID 11793370Read ↗

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The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma.Semantic proximity Read ↗

Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinomaSemantic proximity Read ↗

Different angiogenic potential in low and high grade sporadic clear cell renal cell carcinoma is not related to alterations in the von Hippel-Lindau gene.Semantic proximity Read ↗

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Absence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma.Semantic proximity Read ↗

The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma.Semantic proximity Read ↗

Polymorphisms in the Von Hippel-Lindau Gene Are Associated With Overall Survival in Metastatic Clear-Cell Renal-Cell Carcinoma Patients Treated With VEGFR Tyrosine Kinase Inhibitors.Semantic proximity Read ↗

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