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Clinicopathologic Significance of VHL Gene Alteration in Clear-Cell Renal Cell Carcinoma: An Updated Meta-Analysis and Review.

International journal of molecular sciences - 26 Aug 2018

Kim Hyeong Su, Kim Jung Han, Jang Hyun Joo, Han Boram, Zang Dae Young

Abstract excerpt

The von Hippel-Lindau (VHL) gene is inactivated frequently in sporadic clear-cell renal cell carcinomas (ccRCCs) by genetic alteration (mutation, loss of heterozygosity, or promoter hypermethylation). However, the pathological or prognostic significance of VHL gene alteration has not been well defined. We conducted this meta-analysis to evaluate the association between VHL alteration and clinopathologic findings...

Topics

Adenocarcinoma, Clear Cell
Carcinoma, Renal Cell
DNA Methylation
Genetic Association Studies
Genetic Predisposition to Disease
Genetic Variation
Humans
Mutation
Odds Ratio
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proportional Hazards Models

Publication Bias

Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 30149673
DOI: 10.3390/ijms19092529
PMCID: PMC6165550

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Clinicopathologic Significance of VHL Gene Alteration in Clear-Cell Renal Cell Carcinoma: An Updated Meta-Analysis and Review.PMID 30149673Read ↗

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