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Article

A clearer view of the molecular complexity of clear cell renal cell carcinoma.

Annual review of pathology - 1 Jan 2015

Frew Ian J, Moch Holger

Abstract excerpt

The von Hippel-Lindau (VHL) tumor suppressor gene is mutated as an early event in almost all cases of clear cell renal cell carcinoma (ccRCC), the most frequent form of kidney cancer. In this review we discuss recent advances in understanding how dysregulation of the many hypoxia-inducible factor α-dependent and -independent functions of the VHL tumor suppressor protein (pVHL) can contribute to tumor initiation...

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Topics

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Share to Cancer, Hypoxia, and Metabolism
Share to Carcinoma, Renal Cell
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to VHL gene

Share to Genes, Tumor Suppressor

Share to Kidney Neoplasms

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Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 25387056
DOI: 10.1146/annurev-pathol-012414-040306

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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