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Article

The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2013

Choueiri Toni K, Fay André P, Gagnon Robert, Lin Ying, Bahamon Brittany, Brown Victoria, Rosenberg Jonathan E, Hutson Thomas E, Baker-Neblett Katherine L, Carpenter Christopher, Liu Yuan, Pandite Lini, Signoretti Sabina

Abstract excerpt

PURPOSE: Inactivation of von Hippel-Lindau (VHL) gene in clear-cell renal cell carcinoma (RCC) leads to increased levels of hypoxia-inducible factors (HIF) and overexpression of HIF target genes, such as VEGF and others. VEGF-targeted agents are standard in advanced clear-cell RCC but biomarkers of activity are lacking. EXPERIMENTAL DESIGN: We analyzed tumor tissue samples from metastatic clear-cell RCC patients...

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Source

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Identifiers

PMID: 23881929
DOI: 10.1158/1078-0432.CCR-13-0491
PMCID: PMC4522695

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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