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Article

Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.

Cancer research - 15 May 2002

Turner Kevin J, Moore John W, Jones Adam, Taylor Claire F, Cuthbert-Heavens Darren, Han Cheng, Leek Russell D, Gatter Kevin C, Maxwell Patrick H, Ratcliffe Peter J, Cranston David, Harris Adrian L

Abstract excerpt

The von Hippel-Lindau tumor suppressor protein acts as the substrate recognition component of a ubiquitin E3 ligase that targets hypoxia-inducible factor (HIF)-alpha subunits for proteolysis. Stabilization of HIF-alpha subunits has been described in VHL-defective cell lines, leading to HIF activa...

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Share to Adenocarcinoma, Clear Cell
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Source

Identifiers

PMID: 12019178

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12019178-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.PMID 12019178Read ↗

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