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Article

Genetic pathways involved in carcinogenesis of clear cell renal cell carcinoma: genomics towards personalized medicine.

BJU international - 1 Jun 2012

Audenet François, Yates David R, Cancel-Tassin Géraldine, Cussenot Olivier, Rouprêt Morgan

Abstract excerpt

What's known on the subject? and What does the study add? Sporadic clear cell Renal Cell Carcinoma (ccRCC) is dominated by nutations of the VHL gene located on chromosome 3p in up to 90% of cases. This gene plays a critical role in hypoxia response, including stimulation of neoangiogenesis. Since 2006, anti-angiogenci therapies targeting this pathway are used in metastatic patients with objective response rate as...

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Share to Carcinoma, Renal Cell
Share to Hypoxia-Inducible Factor 1, alpha Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Platelet-Derived Growth Factor

Share to TOR Serine-Threonine Kinases

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Source

Identifiers

PMID: 22035299
DOI: 10.1111/j.1464-410X.2011.10661.x

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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