Mutational analysis of human heat-shock transcription factor 1 reveals a regulatory role for oligomerization in DNA-binding specificity.

doi:10.1042/BJ20090922

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Article

Mutational analysis of human heat-shock transcription factor 1 reveals a regulatory role for oligomerization in DNA-binding specificity.

The Biochemical journal - 11 Nov 2009

Takemori Yukiko, Enoki Yasuaki, Yamamoto Noritaka, Fukai Yo, Adachi Kaori, Sakurai Hiroshi

Abstract excerpt

HSF (heat-shock transcription factor) trimers bind to the HSE (heat-shock element) regulatory sequence of target genes and regulate gene expression. A typical HSE consists of at least three contiguous inverted repeats of the 5-bp sequence nGAAn. Yeast HSF is able to recognize discontinuous HSEs that contain gaps in the array of the nGAAn sequence; however, hHSF1 (human HSF1) fails to recognize such sites in...

Topics

Amino Acid Sequence
DNA
DNA-Binding Proteins
HeLa Cells
Heat Shock Transcription Factors
Humans
Molecular Sequence Data
Mutation
Saccharomyces cerevisiae
Substrate Specificity
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 19758120
DOI: 10.1042/BJ20090922

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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