Article
A Heat Shock-Responsive Domain of Human HSF1 That Regulates Transcription Activation Domain Function
1 Jun 1995
Abstract excerpt
Human heat shock factor 1 (HSF1) stimulates transcription from heat shock protein genes following stress. We have used chimeric proteins containing the GAL4 DNA binding domain to identify the transcriptional activation domains of HSF1 and a separate domain that is capable of regulating activation domain function. This regulatory domain conferred heat shock inducibility to chimeric proteins containing the...
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