Article
The DNA-binding domain of yeast heat shock transcription factor independently regulates both the N- and C-terminal activation domains.
The Journal of biological chemistry - 26 Oct 2001
Bulman A L, Hubl S T, Nelson H C
Abstract excerpt
The expression of heat shock proteins in response to cellular stresses is dependent on the activity of the heat shock transcription factor (HSF). In yeast, HSF is constitutively bound to DNA; however, the mitigation of negative regulation in response to stress dramatically increases transcriptional activity. Through alanine-scanning mutagenesis of the surface residues of the DNA-binding domain, we have identified...
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