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Article

Regulation of Drosophila heat shock factor trimerization: global sequence requirements and independence of nuclear localization.

Molecular and cellular biology - 1 Dec 1996

Orosz A, Wisniewski J, Wu C

Abstract excerpt

Heat shock transcription factor (HSF) is a multidomain protein that exists as a monomer under normal conditions and is reversibly induced upon heat shock to a trimeric state that binds to DNA with high affinity. The maintenance of the monomeric state is dependent on hydrophobic heptad repeats located at the amino- and carboxy-terminal regions which have been proposed to form an intramolecular coiled-coil...

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Identifiers

PMID: 8943357
DOI: 10.1128/MCB.16.12.7018
PMCID: PMC231705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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