Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in human heat shock factor-1 and analysis of potential biological consequences.

Cell stress & chaperones - 1 Jan 2015

Bridges Tiffany M, Scheraga Rachel G, Tulapurkar Mohan E, Suffredini Dante, Liggett Stephen B, Ramarathnam Aparna, Potla Ratnakar, Singh Ishwar S, Hasday Jeffrey D

Abstract excerpt

The stress-activated transcription factor, heat shock factor-1 (HSF1), regulates many genes including cytoprotective heat shock proteins (HSPs). We hypothesized that polymorphisms in HSF1 may alter the level or function of HSF1 protein accounting for interindividual viability in disease susceptibility or prognosis. We searched for exomic variants in HSF1 by querying human genome databases and directly sequencing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to 5' Untranslated Regions

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Databases, Genetic

Share to Heat Shock Transcription Factors

Share to Nucleic Acid Conformation

Share to RNA Interference

Share to RNA, Small Interfering

Share to Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 25023647
DOI: 10.1007/s12192-014-0524-5
PMCID: PMC4255257

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in human heat shock factor-1 and analysis of potential biological consequences.PMID 25023647Read ↗

Association of heat shock proteins with all-cause mortality.Semantic proximity Read ↗

Genetic polymorphism and expression of HSF1 gene is significantly associated with breast cancer in Saudi females.Semantic proximity Read ↗

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.Semantic proximity Read ↗

Determine genetic variations in heat shock factor gene family (HSFs) and study their effect on the functional and structural characterization of protein in Tali goat.Semantic proximity Read ↗

AIRAP, a New Human Heat Shock Gene Regulated by Heat Shock Factor 1Semantic proximity Read ↗

Potential roles for mitochondria-to-HSF1 signaling in health and diseaseSemantic proximity Read ↗

Human coronaviruses activate and hijack the host transcription factor HSF1 to enhance viral replicationSemantic proximity Read ↗

Heat Shock Factor 1-Regulated miRNAs Can Target Huntingtin and Suppress Aggregates of Mutant Huntingtin.Semantic proximity Read ↗

Mutational analysis of human heat-shock transcription factor 1 reveals a regulatory role for oligomerization in DNA-binding specificity.Semantic proximity Read ↗

Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregationSemantic proximity Read ↗

Interactive association of heat shock protein 70 genes variants with natural longevity in Xinjiang Hetian Uygur ethnicity.Semantic proximity Read ↗

Regulation of Cyclooxygenase-2 Expression by Heat: A Novel Aspect of Heat Shock Factor 1 Function in Human CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.