Article
Localisation of endothelin B receptor variants to plasma membrane microdomains and its effects on downstream signalling.
Molecular membrane biology - 1 Aug 2009
Grossmann Solveig, Higashiyama Shigeki, Oksche Alexander, Schaefer Michael, Tannert Astrid
Abstract excerpt
The endothelin B (ET(B)) receptor can undergo a proteolytic cleavage resulting in an unglycosylated N-terminally truncated receptor. We investigated whether ET(B) receptor processing affects caveolar localisation and mitogenic signalling. Distinct subcellular localisations of ET(B) receptor constructs and epidermal growth factor (EGF) receptor ligands were analysed performing detergent-free caveolae preparations...
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