Article
The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent process.
The Journal of biological chemistry - 15 Nov 2002
Grantcharova Evelina, Furkert Jens, Reusch H Peter, Krell Hans-Willi, Papsdorf Gisela, Beyermann Michael, Schulein Ralf, Rosenthal Walter, Oksche Alexander
Abstract excerpt
The extracellular N terminus of the endothelin B (ET(B)) receptor is susceptible to limited proteolysis (cleavage at R64 downward arrow S65), but the regulation and the functional consequences of the proteolysis remain elusive. We analyzed the ET(B) receptor or an ET(B)-GFP fusion protein stably or transiently expressed in HEK293 cells. After incubation of cells at 4 degrees C, only the full-length ET(B) receptor...
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