Article
Cloning and functional identification of novel endothelin receptor type A isoforms in pituitary.
Molecular endocrinology (Baltimore, Md.) - 1 May 2007
Hatae Noriyuki, Aksentijevich Nadia, Zemkova Hana W, Kretschmannova Karla, Tomic Melanija, Stojilkovic Stanko S
Abstract excerpt
Mammalian endothelin (ET) receptors, termed ET(A)R and ET(B)R, are derived from two intron-containing genes and the functional splice variants of ET(B)R but not ET(A)R have been identified. Here, we report about the isolation of cDNAs of ET(A)R transcripts from rat anterior pituitary, which are generated by alternative RNA splicing. Deletion of exon 2 and insertion of fragments from intron 1 and 2 accounted for...
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