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Article

The processing pathway of endothelin-1 production.

Journal of cardiovascular pharmacology - 1 Jan 1998

Kido T, Sawamura T, Masaki T

Abstract excerpt

Production of endothelin (ET-1) is believed to be a three-step process, consisting of an initial proteolytic cleavage by signal peptidase of preproET-1, a second cleavage of proET-1 to big ET-1-Lys-Arg by dibasic amino acid-specific convertase and C-terminal trimming, and finally the processing of Big ET-1 to ET-1 by endothelin-converting enzyme (ECE). To clarify the relationships between the second processing...

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Identifiers

PMID: 9595387
DOI: 10.1097/00005344-199800001-00006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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