N-terminal proteolysis of the endothelin B receptor abolishes its ability to induce EGF receptor transactivation and contractile protein expression in vascular smooth muscle cells.

doi:10.1161/01.ATV.0000220377.51354.30

Article

N-terminal proteolysis of the endothelin B receptor abolishes its ability to induce EGF receptor transactivation and contractile protein expression in vascular smooth muscle cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2006

Grantcharova Evelina, Reusch H Peter, Grossmann Solveig, Eichhorst Jenny, Krell Hans-Willi, Beyermann Michael, Rosenthal Walter, Oksche Alexander

Abstract excerpt

OBJECTIVE: The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent manner, but the physiological role of this N-terminal proteolysis is not known. In this study, we aimed to determine the functional role of the ETB receptor and of its N-terminal cleavage in vascular smooth muscle cells (VSMCs). METHODS AND RESULTS: VSMCs expressing either the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

N-terminal proteolysis of the endothelin B receptor abolishes its ability to induce EGF receptor transactivation and contractile protein expression in vascular smooth muscle cells.

Abstract excerpt

Topics

Related research