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Article

Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor.

The Journal of biological chemistry - 1 Jun 2007

Litterst Claudia, Georgakopoulos Anastasios, Shioi Junichi, Ghersi Enrico, Wisniewski Thomas, Wang Rong, Ludwig Andreas, Robakis Nikolaos K

Abstract excerpt

Binding of EphB receptors to ephrinB ligands on the surface of adjacent cells initiates signaling cascades that regulate angiogenesis, axonal guidance, and neuronal plasticity. These functions require processing of EphB receptors and removal of EphB-ephrinB complexes from the cell surface, but th...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17428795
DOI: 10.1074/jbc.M611449200
PMCID: PMC4005067

Genes

ADAM10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17428795-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor.PMID 17428795Read ↗

Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein.Semantic proximity Read ↗

Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein.Semantic proximity Read ↗

Regulated cleavage of a contact-mediated axon repellent.Semantic proximity Read ↗

Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors.Semantic proximity Read ↗

The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent process.Semantic proximity Read ↗

EphrinA/EphA-induced ectodomain shedding of neural cell adhesion molecule regulates growth cone repulsion through ADAM10 metalloprotease.Semantic proximity Read ↗

Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.Semantic proximity Read ↗

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Missense mutations of the ephrin receptor EPHA1 associated with Alzheimer’s disease disrupt receptor signaling functionsSemantic proximity Read ↗

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase.Semantic proximity Read ↗

Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.Semantic proximity Read ↗

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