Article
Role of the hydrophobic domain in targeting caveolin-1 to lipid droplets.
The Journal of cell biology - 5 Jan 2004
Ostermeyer Anne G, Ramcharan Lynne T, Zeng Youchun, Lublin Douglas M, Brown Deborah A
Abstract excerpt
Although caveolins normally reside in caveolae, they can accumulate on the surface of cytoplasmic lipid droplets (LDs). Here, we first provided support for our model that overaccumulation of caveolins in the endoplasmic reticulum (ER) diverts the proteins to nascent LDs budding from the ER. Next, we found that a mutant H-Ras, present on the cytoplasmic surface of the ER but lacking a hydrophobic peptide domain,...
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