Article
Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution. Identification and epitope mapping of an isoform-specific monoclonal antibody probe.
The Journal of biological chemistry - 7 Jul 1995
Scherer P E, Tang Z, Chun M, Sargiacomo M, Lodish H F, Lisanti M P
Abstract excerpt
Caveolin, an integral membrane protein, is a principal component of caveolae membranes in vivo. Two isoforms of caveolin have been identified: a slower migrating 24-kDa species (alpha-isoform) and a faster migrating 21-kDa species (beta-isoform). Little is known about how these isoforms differ, e...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Biological Transport
- Caveolin 1
- Caveolins
- Cell Compartmentation
- Cells, Cultured
- DNA Mutational Analysis
- DNA, Complementary
- Epitope Mapping
- Fluorescent Antibody Technique
- Genetic Variation