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Article

Agonist-promoted ubiquitination differentially regulates receptor trafficking of endothelin type A and type B receptors.

The Journal of biological chemistry - 19 Dec 2014

Terada Koji, Horinouchi Takahiro, Fujioka Yoichiro, Higashi Tsunehito, Nepal Prabha, Horiguchi Mika, Karki Sarita, Hatate Chizuru, Hoshi Akimasa, Harada Takuya, Mai Yosuke, Ohba Yusuke, Miwa Soichi

Abstract excerpt

Two types of G protein-coupled receptors for endothelin-1 (ET-1), ET type A receptor (ETAR) and ETBR, closely resemble each other, but upon ET-1 stimulation, they follow totally different intracellular trafficking pathways; ETAR is recycled back to plasma membrane, whereas ETBR is targeted to lysosome for degradation. However, the mechanisms for such different fates are unknown. Here we demonstrated that ETBR but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25381251
DOI: 10.1074/jbc.M113.544171
PMCID: PMC4271216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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