Article
Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).
The Journal of infectious diseases - 15 Oct 2009
Le Clerc Sigrid, Limou Sophie, Coulonges Cédric, Carpentier Wassila, Dina Christian, Taing Lieng, Delaneau Olivier, Labib Taoufik, Sladek Rob, Deveau Christiane, Guillemain Hélène, Ratsimandresy Rojo, Montes Matthieu, Spadoni Jean-Louis, Therwath Amu, Schächter François, Matsuda Fumihiko, Gut Ivo, Lelièvre Jean-Daniel, Lévy Yves, Froguel Philippe, Delfraissy Jean-François, Hercberg Serge, Zagury Jean-François
Abstract excerpt
BACKGROUND: Previous genomewide association studies (GWASs) of AIDS have targeted end points based on the control of viral load and disease nonprogression. The discovery of genetic factors that predispose individuals to rapid progression to AIDS should also reveal new insights into the molecular etiology of the pathology. METHODS: We undertook a case-control GWAS of a unique cohort of 85 human immunodeficiency...
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