Article
X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women.
American journal of human genetics - 1 Aug 2009
Siddiqui Roman A, Sauermann Ulrike, Altmüller Janine, Fritzer Elfriede, Nothnagel Michael, Dalibor Nina, Fellay Jacques, Kaup Franz-Josef, Stahl-Hennig Christiane, Nürnberg Peter, Krawczak Michael, Platzer Matthias
Abstract excerpt
AIDS has changed from a mostly male-specific health problem to one that predominantly affects females. Although sex differences in HIV-1 susceptibility are beyond doubt, the extent to which sex affects the onset and progression of AIDS has remained elusive. Here, we provide evidence for an influence of X chromosomal variation on the course of retroviral infection, both in HIV-1-infected patients and in the rhesus...
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