Article
Screening low-frequency SNPS from genome-wide association study reveals a new risk allele for progression to AIDS.
Journal of acquired immune deficiency syndromes (1999) - 1 Mar 2011
Le Clerc Sigrid, Coulonges Cédric, Delaneau Olivier, Van Manen Danielle, Herbeck Joshua T, Limou Sophie, An Ping, Martinson Jeremy J, Spadoni Jean-Louis, Therwath Amu, Veldink Jan H, van den Berg Leonard H, Taing Lieng, Labib Taoufik, Mellak Safa, Montes Matthieu, Delfraissy Jean-François, Schächter François, Winkler Cheryl, Froguel Philippe, Mullins James I, Schuitemaker Hanneke, Zagury Jean-François
Abstract excerpt
BACKGROUND: Seven genome-wide association studies (GWAS) have been published in AIDS, and only associations in the HLA region on chromosome 6 and CXCR6 have passed genome-wide significance. METHODS: We reanalyzed the data from 3 previously published GWAS, targeting specifically low-frequency SNPs (minor allele frequency <5%). Two groups composed of 365 slow progressors and 147 rapid progressors from Europe and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.