Article
Identification of Genes Whose Expression Profile Is Associated with Non-Progression towards AIDS Using eQTLs.
PloS one - 1 Jan 2015
Spadoni Jean-Louis, Rucart Pierre, Le Clerc Sigrid, van Manen Daniëlle, Coulonges Cédric, Ulveling Damien, Laville Vincent, Labib Taoufik, Taing Lieng, Delaneau Olivier, Montes Matthieu, Schuitemaker Hanneke, Noirel Josselin, Zagury Jean-François
Abstract excerpt
BACKGROUND: Many genome-wide association studies have been performed on progression towards the acquired immune deficiency syndrome (AIDS) and they mainly identified associations within the HLA loci. In this study, we demonstrate that the integration of biological information, namely gene expression data, can enhance the sensitivity of genetic studies to unravel new genetic associations relevant to AIDS. METHODS:...
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