Article
Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS.
The Journal of infectious diseases - 15 Feb 2010
Herbeck Joshua T, Gottlieb Geoffrey S, Winkler Cheryl A, Nelson George W, An Ping, Maust Brandon S, Wong Kim G, Troyer Jennifer L, Goedert James J, Kessing Bailey D, Detels Roger, Wolinsky Steven M, Martinson Jeremy, Buchbinder Susan, Kirk Gregory D, Jacobson Lisa P, Margolick Joseph B, Kaslow Richard A, O'Brien Stephen J, Mullins James I
Abstract excerpt
BACKGROUND: A mean of 9-10 years of human immunodeficiency virus type 1 (HIV-1) infection elapse before clinical AIDS develops in untreated persons, but this rate of disease progression varies substantially among individuals. To investigate host genetic determinants of the rate of progression to...
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