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Article

Absence of p16, p21 and p53 gene alterations in hepatocellular carcinomas induced by N-nitrosodiethylamine or a choline-deficient L-amino acid-defined diet in rats.

Cancer letters - 28 Apr 2000

Sasaki Y, Tsujiuchi T, Murata N, Kubozoe T, Tsutsumi M, Konishi Y

Abstract excerpt

To clarify the involvement of tumor suppressor genes in exogenous and endogenous liver carcinogenesis, alterations of p16, p21 and p53 in hepatocellular carcinomas (HCCs) induced by N-nitrosodiethylamine (DEN) and a choline deficient L-amino acid-defined (CDAA) diet in rats were investigated. Male Fischer 344 rats received DEN at 6-week of age followed by partial hepatectomy (PH), with colchicine to induce cell...

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PMID: 10754208
DOI: 10.1016/s0304-3835(99)00430-9

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of p16, p21 and p53 gene alterations in hepatocellular carcinomas induced by N-nitrosodiethylamine or a choline-deficient L-amino acid-defined diet in rats.PMID 10754208Read ↗

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Different mutation patterns of mitochondrial DNA displacement-loop in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient l-amino acid-defined diet in rats.Semantic proximity Read ↗

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p53 mutations in hepatocellular carcinomas induced by a choline-devoid diet in male Fischer 344 rats.Semantic proximity Read ↗

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Mutational activation of H-ras and K-ras genes is absent in N-nitroso-N-methylurea-induced liver tumors in rats.Semantic proximity Read ↗

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