Article
Absence of p16, p21 and p53 gene alterations in hepatocellular carcinomas induced by N-nitrosodiethylamine or a choline-deficient L-amino acid-defined diet in rats.
Cancer letters - 28 Apr 2000
Sasaki Y, Tsujiuchi T, Murata N, Kubozoe T, Tsutsumi M, Konishi Y
Abstract excerpt
To clarify the involvement of tumor suppressor genes in exogenous and endogenous liver carcinogenesis, alterations of p16, p21 and p53 in hepatocellular carcinomas (HCCs) induced by N-nitrosodiethylamine (DEN) and a choline deficient L-amino acid-defined (CDAA) diet in rats were investigated. Mal...
Topics
- Animals
- Carcinogens
- Choline Deficiency
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Diethylnitrosamine
- Food Deprivation
- Genes, p16
- Genes, p53
- Liver Neoplasms, Experimental
- Male
- Mutation
- Rats
- Rats, Inbred F344