Absence of p53 mutations in methylnitrosourea-induced mammary tumors in rats.

Article

Absence of p53 mutations in methylnitrosourea-induced mammary tumors in rats.

Cancer detection and prevention - 1 Jan 1996

Ogawa K, Tokusashi Y, Fukuda I

Abstract excerpt

Administration of methylnitrosourea (MNU) to female rats during or before puberty induces a high incidence of mammary tumors, most of which contain a G to A transition at the second base of H-ras codon 12. However, this mutation alone is presumably not sufficient for normal mammary epithelial cel...

Topics

Animals
Female
Genes, p53
Genes, ras
Mammary Neoplasms, Experimental
Methylnitrosourea
Mutation
Rats
Rats, Inbred F344

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