Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis.

doi:10.1073/pnas.88.3.911

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Article

Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1991

Buchmann A, Bauer-Hofmann R, Mahr J, Drinkwater N R, Luz A, Schwarz M

Abstract excerpt

The frequency and pattern of mutations at codon 61 of the c-Ha-ras gene have been analyzed in 195 liver tumors and 132 precancerous liver lesions from various rodent strains with differing susceptibility to hepatocarcinogenesis. By using the polymerase chain reaction and allele-specific oligonucleotide hybridization, C----A transversions at the first base and A----T transversions or A----G transitions at the...

Topics

Animals
Base Sequence
Codon
Diethylnitrosamine
Ethylnitrosourea
Gene Expression Regulation, Neoplastic
Genes, ras
Genetic Predisposition to Disease
Liver Neoplasms, Experimental
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C3H

Mice, Inbred C57BL

Mice, Inbred Strains

Molecular Sequence Data

Mutation

Oligonucleotide Probes

Polymerase Chain Reaction

Precancerous Conditions

Source

Open in PubMed Open full text

Identifiers

PMID: 1992483
DOI: 10.1073/pnas.88.3.911
PMCID: PMC50924

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1992483-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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