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Article

Incidence of p53 and Ha-ras gene mutations in chemically induced rat mammary carcinomas

1 Oct 1996

Abstract excerpt

To determine whether p53 alterations, which are frequent in human breast cancers, are also common in rat mammary tumors, we examined 40 tumors from 24 rats treated with 7,12-dimethylbenz[a]anthracene (DMBA) and 34 tumors from 14 rats treated with N-nitroso-N-methylurea (NMU) (an N-nitroso compound). DMBA and NMU are known genotoxic mutagens. The entire coding regions of the p53 and Ha-ras genes were examined for...

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Identifiers

PMID: 8890956
DOI: 10.1002/(sici)1098-2744(199610)17:2<78::aid-mc4>3.0.co;2-p

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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