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Article

Point mutation analysis of ras genes in spontaneous and chemically induced C57Bl/10J mouse liver tumours.

Carcinogenesis - 1 Aug 1992

Lord P G, Hardaker K J, Loughlin J M, Marsden A M, Orton T C

Abstract excerpt

The high incidence and profile of ras gene mutations reported in spontaneous and chemically induced liver tumours of the B6C3F1 mouse provides a potential means of determining in vivo genotoxicity and its relevance to carcinogenicity. We analysed spontaneous and chemically induced [with 4-amino-biphenyl (ABP), 2-acetylaminofluorene (AAF) and diethylnitrosamine (DEN)] hepatocellular tumours of the C57Bl/10J mouse...

Topics

2-Acetylaminofluorene
Adenoma
Aminobiphenyl Compounds
Animals
Base Sequence
Carcinoma
DNA
DNA Mutational Analysis
Diethylnitrosamine
Genes, ras
Liver Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Molecular Sequence Data

Mutation

Source

Identifiers

PMID: 1499088
DOI: 10.1093/carcin/13.8.1383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1499088-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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