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Protection of telomeres by a conserved Stn1–Ten1 complex

22 Aug 2007

Abstract excerpt

Telomeres are specialized chromatin structures that protect chromosome ends. Critical among telomere proteins are those that bind the telomeric single-strand DNA (ssDNA) overhangs. These proteins are thought to differ among eukaryotes. Three interacting proteins (Cdc13, Stn1, and Ten1) associate with the telomeric overhang in budding yeast, a single protein known as Pot1 (protection of telomeres-1) performs this...

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PMID: 17715303
DOI: 10.1073/pnas.0705497104

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Protection of telomeres by a conserved Stn1–Ten1 complexPMID 17715303Read ↗

STN1 protects chromosome ends in Arabidopsis thaliana.Semantic proximity Read ↗

DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA.Semantic proximity Read ↗

Tying up the Ends: Plasticity in the Recognition of Single-Stranded DNA at TelomeresSemantic proximity Read ↗

OB Fold-containing Protein 1 (OBFC1), a Human Homolog of Yeast Stn1, Associates with TPP1 and Is Implicated in Telomere Length RegulationSemantic proximity Read ↗

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Semantic proximity Read ↗

Pot1, the putative telomere end-binding protein in fission yeast and humans.Semantic proximity Read ↗

Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.Semantic proximity Read ↗

Evolution of CST function in telomere maintenanceSemantic proximity Read ↗

Structure of the Human Telomeric Stn1-Ten1 Capping ComplexSemantic proximity Read ↗

Human Pot1 (Protection of Telomeres) Protein: Cytolocalization, Gene Structure, and Alternative SplicingSemantic proximity Read ↗

PTOP interacts with POT1 and regulates its localization to telomeres.Semantic proximity Read ↗

Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13.Semantic proximity Read ↗

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