Article
The lack of transcriptional activation of the v-erbA oncogene is in part due to a mutation present in the DNA binding domain of the protein.
Nucleic acids research - 11 Aug 1990
de Verneuil H, Metzger D
Abstract excerpt
Using a transient co-transfection system we have demonstrated that response elements for estrogen (ER), thyroid hormone (TR) and retinoic acid receptors (RAR) are closely related. Thyroid hormone-induced activation of transcription was observed in CV1 cells and not in HeLa cells, suggesting the existence of cell-specific transcription factors necessary for the response. By contrast to its cellular counterpart...
Topics
- Amino Acid Sequence
- Base Sequence
- Binding, Competitive
- Carrier Proteins
- Cell Line
- DNA
- Gene Expression Regulation
- Growth Hormone
- HeLa Cells
- Humans
- Molecular Sequence Data