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Article

The oncoprotein P75gag-v-erbA represses thyroid hormone induced transcription only via response elements containing palindromic half-sites.

Oncogene - 15 Aug 1996

Wahlström G M, Harbers M, Vennström B

Abstract excerpt

The v-erbA oncoprotein P75gag-v-erbA, derived from the thyroid hormone receptor alpha (TR alpha), functions as a transdominant transcriptional repressor. The mechanism by which P75gag-v-erbA acts is however poorly characterized. Here, we show that repression of TR alpha mediated transcription by P75gag-v-erbA in transformed erythroblasts is dependent on the structure of the thyroid hormone response element to...

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PMID: 8761306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The oncoprotein P75gag-v-erbA represses thyroid hormone induced transcription only via response elements containing palindromic half-sites.PMID 8761306Read ↗

Identification of DNA binding sites for the V-erbA oncoprotein, the viral homolog to thyroid hormone receptor alpha.Semantic proximity Read ↗

Rat Rev-erbA alpha, an orphan receptor related to thyroid hormone receptor, binds to specific thyroid hormone response elements.Semantic proximity Read ↗

Thyroid hormone response element organization dictates the composition of active receptor.Semantic proximity Read ↗

Thyroid hormone receptors repress estrogen receptor activation of a TRE.Semantic proximity Read ↗

Distinct dimerization domains provide antagonist pathways for thyroid hormone receptor action.Semantic proximity Read ↗

Thyroid hormone receptor homodimers can function as ligand-sensitive repressors.Semantic proximity Read ↗

v-erbA oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action.Semantic proximity Read ↗

Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers.Semantic proximity Read ↗

v-erbA acts on retinoic acid receptors in immature avian erythroid cells.Semantic proximity Read ↗

Different DNA elements can modulate the conformation of thyroid hormone receptor heterodimer and its transcriptional activity.Semantic proximity Read ↗

Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.Semantic proximity Read ↗

The lack of transcriptional activation of the v-erbA oncogene is in part due to a mutation present in the DNA binding domain of the protein.Semantic proximity Read ↗

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