Article
The oncoprotein P75gag-v-erbA represses thyroid hormone induced transcription only via response elements containing palindromic half-sites.
Oncogene - 15 Aug 1996
Wahlström G M, Harbers M, Vennström B
Abstract excerpt
The v-erbA oncoprotein P75gag-v-erbA, derived from the thyroid hormone receptor alpha (TR alpha), functions as a transdominant transcriptional repressor. The mechanism by which P75gag-v-erbA acts is however poorly characterized. Here, we show that repression of TR alpha mediated transcription by P75gag-v-erbA in transformed erythroblasts is dependent on the structure of the thyroid hormone response element to...
Topics
- Base Sequence
- Biopolymers
- DNA-Binding Proteins
- Gene Products, gag
- HeLa Cells
- Humans
- Kinetics
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Oncogene Proteins v-erbA
- Phenotype
- Promoter Regions, Genetic
- Protein Binding
- Receptors, Retinoic Acid
- Retinoid X Receptors
- Thyroid Hormones
- Transcription Factors
- Transcription, Genetic