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Article

Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.

The EMBO journal - 1 Apr 1993

Barettino D, Bugge T H, Bartunek P, Vivanco Ruiz M D, Sonntag-Buck V, Beug H, Zenke M, Stunnenberg H G

Abstract excerpt

V-erbA is thought to be an antagonist of thyroid hormone receptor (T3R) function. Here we show that unliganded T3R, but not v-erbA, suppresses retinoic acid (RA)-dependent induction of the RAR-beta 2 promoter by competing for the common dimerization partner, the retinoid X receptor (RXR). Firstly, T3R suppression can be alleviated by co-transfection of RXR. Secondly, T3R, but not v-erbA, competes with RAR for RXR...

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Identifiers

PMID: 8096810
DOI: 10.1002/j.1460-2075.1993.tb05779.x
PMCID: PMC413346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.PMID 8096810Read ↗

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