Article
Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.
The EMBO journal - 1 Apr 1993
Barettino D, Bugge T H, Bartunek P, Vivanco Ruiz M D, Sonntag-Buck V, Beug H, Zenke M, Stunnenberg H G
Abstract excerpt
V-erbA is thought to be an antagonist of thyroid hormone receptor (T3R) function. Here we show that unliganded T3R, but not v-erbA, suppresses retinoic acid (RA)-dependent induction of the RAR-beta 2 promoter by competing for the common dimerization partner, the retinoid X receptor (RXR). Firstly...
Topics
- Base Sequence
- Binding, Competitive
- Carbonic Anhydrases
- Carrier Proteins
- Cell Differentiation
- DNA Mutational Analysis
- DNA-Binding Proteins
- Erythroblasts
- Gene Expression Regulation
- In Vitro Techniques
- Ligands
- Molecular Sequence Data
- Mutation
- Oncogene Proteins v-erbA