Article
Transcriptional regulation of human Rev-erbalpha gene expression by the orphan nuclear receptor retinoic acid-related orphan receptor alpha.
The Journal of biological chemistry - 20 Dec 2002
Raspè Eric, Mautino Gisèle, Duval Caroline, Fontaine Coralie, Duez Hélène, Barbier Olivier, Monte Didier, Fruchart Jamila, Fruchart Jean-Charles, Staels Bart
Abstract excerpt
The Rev-erb and retinoic acid-related orphan receptors (ROR) are two related families of orphan nuclear receptors that recognize similar response elements but have opposite effects on transcription. Recently, the Rev-erbalpha gene promoter has been characterized and shown to harbor a functional Rev-erbalpha-binding site known as Rev-DR2, responsible for negative feedback down-regulation of promoter activity by...
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