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Article

v-erbA oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action.

Cell - 6 Sept 1991

Sharif M, Privalsky M L

Abstract excerpt

The v-erbA oncoprotein of avian erythroblastosis virus is an aberrant version of a thyroid hormone receptor and functions in neoplasia by blocking erythroid differentiation and by modifying the growth properties of fibroblasts. v-erbA has been proposed to represent a novel dominant negative oncogene, acting in the cancer cell by interfering with the actions of its normal cell homologs, the thyroid hormone...

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Identifiers

PMID: 1679679
DOI: 10.1016/0092-8674(91)90435-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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v-erbA oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action.PMID 1679679Read ↗

v-erbA acts on retinoic acid receptors in immature avian erythroid cells.Semantic proximity Read ↗

Ontogeny of the v-erbA oncoprotein from the thyroid hormone receptor: an alteration in the DNA binding domain plays a role crucial for v-erbA function.Semantic proximity Read ↗

Association of v-ErbA with Smad4 disrupts TGF-beta signaling.Semantic proximity Read ↗

Multiple mutations contribute to repression by the v-Erb A oncoprotein.Semantic proximity Read ↗

Thyroid hormone receptor/and v-erbA. A single amino acid difference in the C-terminal region influences dominant negative activity and receptor dimer formation.Semantic proximity Read ↗

Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.Semantic proximity Read ↗

Mapping of functional domains within the v-erb A oncogene protein: the remnants of the hormone binding domain play multiple, vital roles in protein action.Semantic proximity Read ↗

The oncoprotein P75gag-v-erbA represses thyroid hormone induced transcription only via response elements containing palindromic half-sites.Semantic proximity Read ↗

The carbonic anhydrase II gene, a gene regulated by thyroid hormone and erythropoietin, is repressed by the v-erbA oncogene in erythrocytic cells.Semantic proximity Read ↗

Requirement for the C-terminal domain of the v-erbA oncogene protein for biological function and transcriptional repression.Semantic proximity Read ↗

Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosisSemantic proximity Read ↗

The RET oncogene is a critical component of transcriptional programs associated with retinoic acid–induced differentiation in neuroblastomaSemantic proximity Read ↗

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