v-erbA oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action.

doi:10.1016/0092-8674(91)90435-2

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Article

v-erbA oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action.

Cell - 6 Sept 1991

Sharif M, Privalsky M L

Abstract excerpt

The v-erbA oncoprotein of avian erythroblastosis virus is an aberrant version of a thyroid hormone receptor and functions in neoplasia by blocking erythroid differentiation and by modifying the growth properties of fibroblasts. v-erbA has been proposed to represent a novel dominant negative oncogene, acting in the cancer cell by interfering with the actions of its normal cell homologs, the thyroid hormone...

Topics

Alleles
Amino Acid Sequence
Animals
Birds
Carrier Proteins
Cells, Cultured
DNA-Binding Proteins
Gene Expression Regulation
Humans
In Vitro Techniques
Molecular Sequence Data
Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

Oncogene Proteins v-erbA

Receptors, Estrogen

Receptors, Retinoic Acid

Retroviridae Proteins, Oncogenic

Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 1679679
DOI: 10.1016/0092-8674(91)90435-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1679679-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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v-erbA oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action.PMID 1679679Read ↗

v-erbA acts on retinoic acid receptors in immature avian erythroid cells.Semantic proximity Read ↗

Ontogeny of the v-erbA oncoprotein from the thyroid hormone receptor: an alteration in the DNA binding domain plays a role crucial for v-erbA function.Semantic proximity Read ↗

Association of v-ErbA with Smad4 disrupts TGF-beta signaling.Semantic proximity Read ↗

Multiple mutations contribute to repression by the v-Erb A oncoprotein.Semantic proximity Read ↗

Thyroid hormone receptor/and v-erbA. A single amino acid difference in the C-terminal region influences dominant negative activity and receptor dimer formation.Semantic proximity Read ↗

Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.Semantic proximity Read ↗

Mapping of functional domains within the v-erb A oncogene protein: the remnants of the hormone binding domain play multiple, vital roles in protein action.Semantic proximity Read ↗

The oncoprotein P75gag-v-erbA represses thyroid hormone induced transcription only via response elements containing palindromic half-sites.Semantic proximity Read ↗

The carbonic anhydrase II gene, a gene regulated by thyroid hormone and erythropoietin, is repressed by the v-erbA oncogene in erythrocytic cells.Semantic proximity Read ↗

Requirement for the C-terminal domain of the v-erbA oncogene protein for biological function and transcriptional repression.Semantic proximity Read ↗

Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosisSemantic proximity Read ↗

The RET oncogene is a critical component of transcriptional programs associated with retinoic acid–induced differentiation in neuroblastomaSemantic proximity Read ↗

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