Article
Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.
PLoS pathogens - 1 Sept 2009
Intemann Christopher D, Thye Thorsten, Niemann Stefan, Browne Edmund N L, Amanua Chinbuah Margaret, Enimil Anthony, Gyapong John, Osei Ivy, Owusu-Dabo Ellis, Helm Susanne, Rüsch-Gerdes Sabine, Horstmann Rolf D, Meyer Christian G
Abstract excerpt
The human immunity-related GTPase M (IRGM) has been shown to be critically involved in regulating autophagy as a means of disposing cytosolic cellular structures and of reducing the growth of intracellular pathogens in vitro. This includes Mycobacterium tuberculosis, which is in agreement with findings indicating that M. tuberculosis translocates from the phagolysosome into the cytosol of infected cells, where it...
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